Research

The European Partnership for the Assessment of Risks from Chemicals aims to develop next-generation chemical risk assessment to protect human health and the environment. It supports the European Union’s Chemicals Strategy for Sustainability and the European Green Deal’s “Zero pollution” ambition.

This project aims to identify pesticide-induced adverse effects related to oxidative stress that are relevant to both human health and ecosystems, within the One Health framework. It will develop an innovative research strategy based on Adverse Outcome Pathways (AOPs) through a pan-European, interdisciplinary network bringing together scientists, regulators, and stakeholders. The outcomes will support risk assessment and policymaking, in synergy with existing international initiatives.

The project proposes to develop and apply a new method for studying the interactions between environmental exposure and genetic risk factors, at the intersection of large-scale genetic studies and studies of the impact of environmental factors, focusing on metabolic diseases. The project is based on the development of a method for extracting environmental risks coupled with the advancement of new methods for analyzing interactions and the availability and accessibility of large databases.

This Booster program combines multiple approaches to identify associations between components of the exposome and health events at multiple scales but also to better define causal links between them.

ANR/DFG collaborative Franco-german project that focus on SDHi (succinate dehydrogenase inhibitors), a family of fungicides. The overall objective is to fill a large gap of knowledge regarding the neurodevelopemental toxicity of SHDi fungicides using an integrated approach and several complementary in vivo, in vitro and in silico (AOP development) models.

The ENDOFAT project will study the interactions between xenobiotics, adipose tissue and endometriotic lesions using an integrative approach.

The ELIXIR Toxicology community is co-leaded by SysTox (K. Audouze). The main goal is to support the integration of standards, tools and resources to support toxicology research projects and risk governance at the national and international levels.

France Exposome supports research in the environmental health field, leading to a better understanding of the existing associations between chemical exposures and health outcomes related to chronic diseases.

The aim of the project is to build an integrated approach for testing and assessment (IATA) to detect endocrine disruptors-related metabolic disorders by developing, improving and validating a battery of test systems. Project part of the EURION cluster.

Systems toxicology of pollutant mixture released from grafted adipose tissue.

Artificial intelligence to assess the impact of the chemical exposome on breast cancer and its societal cost: towards an integrated and interdisciplinary approach for public health.

HBM4EU: H2020 project with the aim of coordinating and advancing human biomonitoring in Europe to provide evidence for chemical policy making.

HERA : H2020 project – The overall aim of the HERA project is to set the priorities for an envionment, climate and health reserach agenda in the EU.

A self-questionnaire to enable researchers to assess the status of their in vitro test for endocrine disruptors.

Ecophyto II+ plan : Study of the effects from exposure to agrochemicals on the cognitive and psychomotor development of children.

INCa et IRESP project: Co-exposure to cigarette smoke and tumor microenvironment & breast cancer aggressiveness.