Publications & Communications
© Tous droits réservés
Peer-reviewed journal articles
- Combining the Classification and Pharmacophore Approaches to Understand Homogeneous Olfactory Perceptions at Peripheral Level: Focus on Two Aroma Mixtures.
Rugard M, Audouze K, Tromelin A.
Molecules. 2023 May 11;28(10):4028. doi: 10.3390/molecules28104028. - ReadEDTest: A tool to assess the readiness of in vitro test methods under development for identifying endocrine disruptors
Crouzet T, Grignard E, Brion F, Blanc EB, Podechard N, Langouet S, Alonso-Magdalena P, Hubert P, Kim MJ, Audouze K.
Environ Int. 2023 Apr;174:107910. doi: 10.1016/j.envint.2023.107910. Epub 2023 Mar 31. - Integrating -omics approaches into population-based studies of endocrine disrupting chemicals: A scoping review.
Maitre L, Jedynak P, Gallego M, Ciaran L, Audouze K, Casas M, Vrijheid M.
Environ Res. 2023 Jul 1;228:115788. doi: 10.1016/j.envres.2023.115788. Epub 2023 Mar 31. - Gene-environment interactions in the associations of PFAS exposure with insulin sensitivity and beta-cell function in a Faroese cohort followed from birth to adulthood.
Valvi D, Christiani DC, Coull B, Højlund K, Nielsen F, Audouze K, Su L, Weihe P, Grandjean P.
Environ Res. 2023 Jun 1;226:115600. doi: 10.1016/j.envres.2023.115600. Epub 2023 Mar 1. - Childhood exposure to non-persistent endocrine disrupting chemicals and multi-omic profiles: A panel study.
Fabbri L, Garlantézec R, Audouze K, Bustamante M, Carracedo Á, Chatzi L, Ramón González J, Gražulevičienė R, Keun H, Lau CE, Sabidó E, Siskos AP, Slama R, Thomsen C, Wright J, Lun Yuan W, Casas M, Vrijheid M, Maitre L.
Environ Int. 2023 Mar;173:107856. doi: 10.1016/j.envint.2023.107856. Epub 2023 Feb 26. - Cigarette smoke and tumor microenvironment copromote aggressiveness of human breast cancer cells.
Benoit L, Tomkiewicz C, Delit M, Khider H, Audouze K , Kowandy F, Bortoli S, Barouki R, Coumoul K, Koual M.
Toxicol Sci. 2023 Mar 20;192(1):30-42. doi: 10.1093/toxsci/kfad013. - Application of AOPs to assist regulatory assessment of chemical risks – Case studies, needs and recommendations.
Bajard L, Adamovsky O, Audouze K , Baken K, Barouki R , Beltman JB, Beronius A, Bonefeld-Jørgensen EC, Cano-Sancho G, de Baat ML, Di Tillio F, Fernández MF, FitzGerald RE, Gundacker C, Hernández AF, Hilscherova K, Karakitsios S, Kuchovska E, Long M, Luijten M, Majid S, Marx-Stoelting P, Mustieles V, Negi CK, Sarigiannis D, Scholtz S, Sovadinova I, Stierum R, Tanabe S, Tollefsen KE, van den Brand AD, Vogs C, Wielsøe M, Wittwehr C, Blaha L.
Environ Res. 2023 Jan 15;217:114650. doi: 10.1016/j.envres.2022.114650. Epub 2022 Oct 27.
2022
Peer-reviewed journal articles
- Partitioning of Persistent Organic Pollutants between Adipose Tissue and Serum in Human Studies.
Moriceau MA, Cano-Sancho G, Kim M, Coumoul X, , Emond C, Arrebola JP, Antignac JP, Audouze K, , Rousselle C.
Toxics. 2022 Dec 31;11(1):41. doi: 10.3390/toxics11010041. - Reduced Birth Weight and Exposure to Per- and Polyfluoroalkyl Substances: A Review of Possible Underlying Mechanisms Using the AOP-HelpFinder.
Gundacker C,Audouze K ,Widhalm R, Granitzer S, Forsthuber M, Jornod F, Wielsøe M, Long M, Halldórsson TI, Uhl M, Bonefeld-Jørgensen EC.
Toxics. 2022 Nov 12;10(11):684. doi: 10.3390/toxics10110684 - Application of artificial intelligence to decode the relationships between smell, olfactory receptors and small molecules
Achebouche R, Tromelin A, Audouze K , Taboureau O.
Sci Rep. 2022 Nov 5;12(1):18817. doi: 10.1038/s41598-022-23176-y. - Application of AOPs to assist regulatory assessment of chemical risks – Case studies, needs and recommendations.
Bajard L, Adamovsky O, Audouze K , Baken K, Barouki R , Beltman JB, Beronius A, Bonefeld-Jørgensen EC, Cano-Sancho G, de Baat ML, Di Tillio F, Fernández MF, FitzGerald RE, Gundacker C, Hernández AF, Hilscherova K, Karakitsios S, Kuchovska E, Long M, Luijten M, Majid S, Marx-Stoelting P, Mustieles V, Negi CK, Sarigiannis D, Scholtz S, Sovadinova I, Stierum R, Tanabe S, Tollefsen KE, van den Brand AD, Vogs C, Wielsøe M, Wittwehr C, Blaha L.
Environ Res. 2022 Oct 26:114650. doi: 10.1016/j.envres.2022.114650. Epub ahead of print. - Radiation Adverse Outcome Pathways (AOPs) are on the Horizon: Advancing Radiation Protection through an International Horizon-Style Exercisewe
Burtt JJ, Leblanc J, Randhawa K, Ivanova A, Rudd MA, Wilkins R, Azzam EI, Hecker M, Horemans N, Vandenhove H, Adam-Guillermin C, Armant O, Klokov D, Audouze K, Kaiser JC, Moertl S, Lumniczky K, Tanaka IB 3rd, Yamada Y, Hamada N, Al-Nabulsi I, Preston J, Bouffler S, Applegate K, Cool D, Beaton D, Tollefsen KE, Garnier-Laplace J, Laurier D, Chauhan V.
Int J Radiat Biol. 2022 Sep 6:1-34. doi: 10.1080/09553002.2022.2121439.. - Developing human biomonitoring as a 21st century toolbox within the European exposure science strategy 2020-2030
Zare Jeddi M, Hopf NB, Louro H, Viegas S, Galea KS, Pasanen-Kase R, Santonen T, Mustieles V, Fernandez MF, Verhagen H, Bopp SK, Antignac JP, David A, Mol H, Barouki R, Audouze K, Duca RC, Fantke P, Scheepers P, Ghosh M, Van Nieuwenhuyse A, Lobo Vicente J, Trier X, Rambaud L, Fillol C, Denys S, Conrad A, Kolossa-Gehring M, Paini A, Arnot J, Schulze F, Jones K, Sepai O, Ali I, Brennan L, Benfenati E, Cubadda F, Mantovani A, Bartonova A, Connolly A, Slobodnik J, Bruinen de Bruin Y, van Klaveren J, Palmen N, Dirven H, Husøy T, Thomsen C, Virgolino A, Röösli M, Gant T, von Goetz N, Bessems J.
Int. 2022 Aug 28;168:107476. doi: 10.1016/j.envint.2022.107476.. - Development of an adverse outcome pathway for radiation-induced microcephaly via expert consultation and machine learning
Jaylet T, Quintens R, Benotmane MA, Luukkonen J, Tanaka IB 3rd, Ibanez C, Durand C, Sachana M, Azimzadeh O, Adam-Guillermin C, Tollefsen KE, Laurent O, Audouze K, Armant O.
Int J Radiat Biol. 2022 Aug 18:1-11. doi: 10.1080/09553002.2022.2110312. - Combinatorial pathway disruption is a powerful approach to delineate metabolic impacts of endocrine disruptors.
Bernal K, Touma C, Erradhouani C, Boronat-Belda T, Gaillard L, Al Kassir S, Le Mentec H, Martin-Chouly C, Podechard N, Lagadic-Gossmann D, Langouet S, Brion F, Knoll-Gellida A, Babin PJ, Sovadinova I, Babica P, Andreau K, Barouki R, Vondracek J, Alonso-Magdalena P, Kim MJ, Coumoul X.
FEBS Lett. 2022 Aug 11. doi: 10.1002/1873-3468.14465. - Characterization of Potential Adverse Outcome Pathways Related to Metabolic Outcomes and Exposure to Per- and Polyfluoroalkyl Substances Using Artificial Intelligence.
Kaiser AM, Zare Jeddi M, Uhl M, Jornod F, Fernandez MF, Audouze K.
Toxics. 2022 Aug 4;10(8):449. doi: 10.3390/toxics10080449. - Adverse outcome pathway from activation of the AhR to breast cancer-related death
Benoit L, Jornod F, Zgheib E, Tomkiewicz C, Koual M, Coustillet T, Barouki R, Audouze K, Vinken M, Coumoul X.
Environ Int. 2022 Jul;165:107323. doi: 10.1016/j.envint.2022.107323 - Obesity III: Obesogen assays: Limitations, strengths, and new directions.
Kassotis CD, Vom Saal FS, Babin PJ, Lagadic-Gossmann D, Le Mentec H, Blumberg B, Mohajer N, Legrand A, Munic Kos V, Martin-Chouly C, Podechard N, Langouët S, Touma C, Barouki R, Kim MJ, Audouze K, Choudhury M, Shree N, Bansal A, Howard S, Heindel JJ.
Pharmacol. 2022 May;199:115014. doi: 10.1016/j.bcp.2022.115014 - Obesity II: Establishing causal links between chemical exposures and obesity.
Heindel JJ, Howard S, Agay-Shay K, Arrebola JP, Audouze K, Babin PJ, Barouki R, Bansal A, Blanc E, Cave MC, Chatterjee S, Chevalier N, Choudhury M, Collier D, Connolly L, Coumoul X, Garruti G, Gilbertson M, Hoepner LA, Holloway AC, Howell G 3rd, Kassotis CD, Kay MK, Kim MJ, Lagadic-Gossmann D, Langouet S, Legrand A, Li Z, Le Mentec H, Lind L, Monica Lind P, Lustig RH, Martin-Chouly C, Munic Kos V, Podechard N, Roepke TA, Sargis RM, Starling A, Tomlinson CR, Touma C, Vondracek J, Vom Saal F, Blumberg B.
Biochem Pharmacol. 2022 May;199:115015. doi: 10.1016/j.bcp.2022.115015 - Obesity I: Overview and molecular and biochemical mechanisms.
Lustig RH, Collier D, Kassotis C, Roepke TA, Kim MJ, Blanc E, Barouki R, Bansal A, Cave MC, Chatterjee S, Choudhury M, Gilbertson M, Lagadic-Gossmann D, Howard S, Lind L, Tomlinson CR, Vondracek J, Heindel JJ.
Biochem Pharmacol. 2022 May;199:115012. doi: 10.1016/j.bcp.2022.115012 - TCDD aggravates the formation of the atherosclerotic plaque in ApoE KO mice with a sexual dimorphic pattern.
Bey L, Coumoul X, Kim MJ
Biochimie. 2022 Apr;195:54-58. doi: 10.1016/j.biochi.2022.01.012 - Merging the exposome into an integrated framework for “omics” sciences.
Price EJ, Vitale CM, Miller GW, David A, Barouki R, Audouze K, Walker DI, Antignac JP, Coumoul X, Bessonneau V, Klánová J
iScience. 2022 Feb 24;25(3):103976. doi: 10.1016/j.isci.2022.103976 - Perturbateurs endocriniens : un risque débattu
Hill C, Barouki R, Audouze K, Coumoul X,
La revue du praticien , 2022 Jan 21; 72(1);13-6 - Emerging Bioinformatics Methods and Resources in Drug Toxicology
Taboureau O, Audouze K.
Methods Mol Biol. 2022;2425:133-146. doi: 10.1007/978-1-0716-1960-5_6
2021
- Mitochondrial Dysfunction as a Hallmark of Environmental Injury.
Duarte-Hospital C, Tête A, Brial F, Benoit L, Koual M, Tomkiewicz C, Kim MJ, Blanc EB, Coumoul X, Bortoli S.
Cells. 2021 Dec 30;11(1):110. doi: 10.3390/cells11010110 - Capturing a Comprehensive Picture of Biological Events From Adverse Outcome Pathways in the Drug Exposome.
Wu Q, Bagdad Y, Taboureau O, Audouze K.
Front Public Health. 2021; Dec 17 9:763962. doi:10.3389/fpubh.2021.763962 - The exposome and toxicology: a win-win collaboration.
Barouki R, Audouze K, Becker C, Blaha L,Coumoul X,Karakitsios S, Klanova J, Miller GW, Price EJ, Sarigiannis D.
Toxicol Sci. 2021 Dec 8:kfab149. doi: 10.1093/toxsci/kfab149. Online ahead of print. - Development of a chemogenomics library for phenotypic screening.
Dafniet B, Cerisier N, Boezio B, Clary A, Ducrot P, Dorval T, Gohier A, Brown D, Audouze K,Taboureau O.
J Cheminform. 2021 Nov 24;13(1):91. doi: 10.1186/s13321-021-00569-1 - AOP-helpFinder webserver: a tool for comprehensive analysis of the literature to support adverse outcome pathways development
Jornod F, Jaylet T, Blaha L, Sarigiannis D, Tamisier L, Audouze K.
Bioinformatics. 2021 Oct 30;38(4):1173–5. doi: 10.1093/bioinformatics/btab750. - Que sait on de l’action des perturbateurs endocriniens sur le métabolisme et l’obésité?
Kim Min J, Blanc E. Audouze K.
La revue du praticien, 2021 Sept. 27 ;71(7):723)-6 - Perturbateurs endocriniens: de quoi parle t’on, et quels nouveaux mécanismes de toxicité mettent ils en jeu?
Barouki R, Audouze K, Coumoul X.
La revue du praticien, 2021 Sept. 27 ;71(7):723)-6 - Associations between Exposure to Organochlorine Chemicals and Endometriosis: A Systematic Review of Experimental Studies and Integration of Epidemiological Evidence
Matta K, Koual M, Ploteau S, Coumoul X, Audouze K, Le Bizec B, Antignac JP, Cano-Sancho G
Environ Health Perspect. 2021 Jul;129(7):76003. doi: 10.1289/EHP8421 - Identification of non-validated endocrine disrupting chemical characterization methods by screening of the literature using artificial intelligence and by database exploration.
Zgheib E, Kim MJ, Jornod F, Bernal K, Tomkiewicz C, Bortoli S, Coumoul X, Barouki R, De Jesus K, Grignard E, Hubert P, Katsanou ES, Busquet F, Audouze K.
Environ Int. 2021 Apr 23;154:106574. doi: 10.1016/j.envint.2021.106574. Online ahead of print. - Smell compounds classification using UMAP to increase knowledge of odors and molecular structures linkages.
Rugard M, Jaylet T, Taboureau O, Tromelin A, Audouze K.
PLoS One. 2021 May 28;16(5):e0252486. doi: 10.1371/journal.pone.0252486. eCollection 2021. - Endocrine Disrupting Chemicals: Current Understanding, New Testing Strategies and Future Research Needs.
Street ME, Audouze K, Legler J, Sone H, Palanza P.
Int J Mol Sci. 2021 Jan 19;22(2):933. doi: 10.3390/ijms22020933. - Development of an adverse drug event network to predict drug toxicity
Q Wu, O Taboureau, K Audouze
Current Research in Toxicology 1, 48-55
2020
2020
- The COVID-19 pandemic and global environmental change: Emerging research needs.
Barouki R, Kogevinas M, Audouze K, Belesova K, Bergman A, Birnbaum L, Boekhold S, Denys S, Desseille C, Drakvik E, Frumkin H, Garric J, Destoumieux-Garzon D, Haines A, Huss A, Jensen G, Karakitsios S, Klanova J, Koskela IM, Laden F, Marano F, Franziska Matthies-Wiesler E, Morris G, Nowacki J, Paloniemi R, Pearce N, Peters A, Rekola A, Sarigiannis D, Šebková K, Slama R, Staatsen B, Tonne C, Vermeulen R, Vineis P; HERA-COVID-19 working group.
Environ Int. 2021 Jan;146:106272. doi: 10.1016/j.envint.2020.106272. Epub 2020 Nov 19. - Endocrine disrupting chemicals and COVID-19 relationships: A computational systems biology approach.
Wu Q, Coumoul X, Grandjean P, Barouki R, Audouze K.
Environ Int. 2020 Oct 30:106232. doi: 10.1016/j.envint.2020.106232. Online ahead of print. - Drug-target-ADR Network and Possible Implications of Structural Variants in Adverse Events.
Dafniet B, Cerisier N, Audouze K, Taboureau O
Mol Inform. 2020 Dec;39(12):e2000116. doi: 10.1002/minf.202000116. Epub 2020 Aug 28. - AOP4EUpest: mapping of pesticides in adverse outcome pathways using a text mining tool.
Jornod F, Rugard M, Tamisier L, Coumoul X, Andersen HR, Barouki R, Audouze K.
Bioinformatics. 2020 Aug 1;36(15):4379-4381. doi: 10.1093/bioinformatics/btaa545 - Integrative systems toxicology to predict human biological systems affected by exposure to environmental chemicals.
Taboureau O, El M’Selmi W, Audouze K.
Toxicol Appl Pharmacol. 2020 Oct 15;405:115210. doi: 10.1016/j.taap.2020.115210. Epub 2020 Aug 27 - Exploring the Characteristics of an Aroma-Blending Mixture by Investigating the Network of Shared Odors and the Molecular Features of Their Related Odorants.
Tromelin A, Koensgen F, Audouze K, Guichard E, Thomas-Danguin T.
Molecules. 2020 Jul 2;25(13):3032. doi: 10.3390/molecules25133032. - Endocrine disrupting chemicals and COVID-19 relationships: a computational systems biology approach.
Wu Q, Coumoul X, Grandjean P, Barouki R, Audouze K.
medRxiv. 2020 Jul 15:2020.07.10.20150714. doi: 10.1101/2020.07.10.20150714. Preprint. - Integrative Strategy of Testing Systems for Identification of Endocrine Disruptors Inducing Metabolic Disorders-An Introduction to the OBERON Project.
Audouze K, Sarigiannis D, Alonso-Magdalena P, Brochot C, Casas M, Vrijheid M, Babin PJ, Karakitsios S, Coumoul X, Barouki R.
Int J Mol Sci. 2020 Apr 23;21(8):2988. doi: 10.3390/ijms21082988. - Computational systems biology as an animal-free approach to characterize toxicological effects of persistent organic pollutants.
Wu Q, Achebouche R, Audouze K.
ALTEX. 2020;37(2):287-299. doi: 10.14573/altex.1910161. Epub 2020 Jan 21. - Deciphering Adverse Outcome Pathway Network Linked to Bisphenol F Using Text Mining and Systems Toxicology Approaches.
Rugard M, Coumoul X, Carvaillo JC, Barouki R, Audouze K.
Toxicol Sci. 2020 Jan 1;173(1):32-40. doi: 10.1093/toxsci/kfz214.
2019
2019
- Integrative Strategy of Testing Systems for Identification of Endocrine Disruptors Inducing Metabolic Disorders.
K Audouze, M Vrijheid, C Brochot, PJ Babin, Dimosthenis Sarigiannis, Spyridon Karakitsios, M Casas, R Barouki, P Alonso-Magdalena, X Coumoul
International Journal of Molecular Sciences - sAOP: linking chemical stressors to adverse outcomes pathway networks.
Aguayo-Orozco A, Audouze K, Siggaard T, Barouki R, Brunak S, Taboureau O.
Bioinformatics. 2019 Dec 15;35(24):5391-5392. doi: 10.1093/bioinformatics/btz570. - Conflicting associations between dietary patterns and changes of anthropometric traits across subgroups of middle-aged women and men.
Jiang L, Audouze K, Romero Herrera JA, Ängquist LH, Kjærulff SK, Izarzugaza JMG, Tjønneland A, Halkjær J, Overvad K, Sørensen TIA, Brunak S.
Clin Nutr. 2020 Jan;39(1):265-275. doi: 10.1016/j.clnu.2019.02.003. Epub 2019 Feb 14. - Linking Bisphenol S to Adverse Outcome Pathways Using a Combined Text Mining and Systems Biology Approach.
Carvaillo JC, Barouki R, Coumoul X, Audouze K.
Environ Health Perspect. 2019 Apr;127(4):47005. doi: 10.1289/EHP4200. - Multivariate statistical analysis of a large odorants database aimed at revealing similarities and links between odorants and odors
A Tromelin, C Chabanet, K Audouze, F Koensgen, E Guichard
Flavour and Fragrance Journal 33 (1), 106-126 - Epigenetics as a mechanism linking developmental exposures to long-term toxicity
R Barouki, E Melén, Z Herceg, J Beckers, J Chen, M Karagas, A Puga, Y Xia, L Chadwick, W Yan, K Audouze, R Slama, J Heindel, P Grandjean, T Kawamoto, K Nohara
Environment international 114, 77-86
2018
2018
- Integration of the human exposome with the human genome to advance medicine.
Barouki R, Audouze K, Coumoul X, Demenais F, Gauguier D.
Biochimie. 2018 Sep;152:155-158. doi: 10.1016/j.biochi.2018.06.023. Epub 2018 Jun 28. - Epigenetics as a mechanism linking developmental exposures to long-term toxicity.
Barouki R, Melén E, Herceg Z, Beckers J, Chen J, Karagas M, Puga A, Xia Y, Chadwick L, Yan W, Audouze K, Slama R, Heindel J, Grandjean P, Kawamoto T, Nohara K
Environ Int. 2018 May;114:77-86. doi: 10.1016/j.envint.2018.02.014. Epub 2018 Feb 27. - A systems biology approach to predictive developmental neurotoxicity of a larvicide used in the prevention of Zika virus transmission.
Audouze K, Taboureau O, Grandjean P.
Toxicol Appl Pharmacol. 2018 Sep 1;354:56-63. doi: 10.1016/j.taap.2018.02.014. Epub 2018 Feb 21.
2017
2017
- Network-based Approaches in Pharmacology.
Boezio B, Audouze K, Ducrot P, Taboureau O.
Mol Inform. 2017 Oct;36(10). doi: 10.1002/minf.201700048. Epub 2017 Jul 10.
2016
2016
- Human Environmental Disease Network: A computational model to assess toxicology of contaminants.
Taboureau O,Audouze K
ALTEX. 2017;34(2):289-300. doi: 10.14573/altex.1607201. Epub 2016 Oct 21.
Examples of Press-releases
2020
2019
Conference presentations (oral and posters)
The SysTox group is present at various international events (SETAC, SOT, EuroTox, Estiv…)
And some more …
2021
2020
- Fête de la science: Qu’est ce que la pandémie Covid-19 nous apprend de notre relation santé-environnement?
- Tour des sciences: Les AOPs pour tous!
- Journées des patients Inserm
- Le lycée au labo: la bioinformatique
- Société Francophone de Santé et Environnement/ M. Rugard
2019