Humans are constantly exposed to a huge number of environmental factors that may be linked to potential toxicities via multiple mechanisms and biological processes.

How does toxicology deal with this complex reality today?

SysTox’s vision is to combine computational toxicology with experimental studies of molecular interactions between cells and chemicals, providing a powerful alternative to animal testing for advancing the understanding of adverse health effects of exposures.

We develop and apply integrative systems biology & bioinformatics methods to explore and predict the complexity of the biology on both integrative and systemic levels. SysTox leads and is involved in several French and European projects.

The SysTox team, led by Prof. Karine Audouze, is part of the INSERM HealthFex Unit (UMRS 1124) at the Université Paris Cité.