Publications & Communications
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Peer-reviewed journal articles
2023
Peer-reviewed journal articles
- TNS1 and NRXN1 Genes Interacting With Early-Life Smoking Exposure in Asthma-Plus-Eczema Susceptibility.
Allergy AsthmaImmunol Res. 2023 Nov;15(6):779-794. doi:10.4168/aair.2023.15.6.779.PMID: 37957795
- Xenobiotic Exposure and Migraine-Associated Signaling: A Multimethod Experimental Study Exploring Cellular Assays in Combination with Ex Vivo and In Vivo Mouse Models.
Environ Health Perspect. 2023 Nov;131(11):117003. doi: 10.1289/EHP12413. Epub 2023 Nov 1.PMID: 37909725
- ELIXIR and Toxicology: a community in development.
Martens M, Stierum R, Schymanski EL, Evelo CT, Aalizadeh R, Aladjov H, Arturi K, Audouze K , Babica P, Berka K, Bessems J, Blaha L, Bolton EE, Cases M, Damalas DΕ, Dave K, Dilger M, Exner T, Geerke DP, Grafström R, Gray A, Hancock JM, Hollert H, Jeliazkova N, Jennen D, Jourdan F, Kahlem P, Klanova J, Kleinjans J, Kondic T, Kone B, Lynch I, Maran U, Martinez Cuesta S, Ménager H, Neumann S, Nymark P, Oberacher H, Ramirez N, Remy S, Rocca-Serra P, Salek RM, Sallach B, Sansone SA, Sanz F, Sarimveis H, Sarntivijai S, Schulze T, Slobodnik J, Spjuth O, Tedds J, Thomaidis N, Weber RJM, van Westen GJP, Wheelock CE, Williams AJ, Witters H, Zdrazil B, Županič A, Willighagen EL.
F1000Res. 2023 Oct 3;10:ELIXIR-1129. doi: 10.12688/f1000research.74502.2 - The effects of pollutant mixture released from grafted adipose tissues on fatty acid and lipid metabolism in the skeletal muscles, kidney, heart, and lungs of male mice.
Environ Pollut. 2023 Aug 15;336:122387. doi: 10.1016/j.envpol.2023.122387.
- NMR metabolomics study of chronic low-dose exposure to a cocktail of persistent organic pollutants.
NMR Biomed. 2023
Nov;36(11):e5006. doi: 10.1002/nbm.5006. Epub 2023 Jul 31.PMID: 37524504 - An integrative systems biology strategy to support the development of adverse outcome pathways (AOPs): a case study on radiation-induced microcephaly.
Jaylet T, Quintens R, Armant O, Audouze K.
Front Cell Dev Biol. 2023 Jun 22;11:1197204. doi: 10.3389/fcell.2023.1197204. - Prenatal exposure to multiple persistent organic pollutants in association with adiposity markers and blood pressure in preadolescents.
Rouxel E, Costet N, Monfort C, Audouze K, Cirugeda L, Gaudreau E, Grimalt JO, Ibarluzea J, Lainé F, Llop S, Lopez-Espinosa MJ, Rouget F, Santa-Marina L, Vrijheid M, Chevrier C, Casas M, Warembourg C.
Environ Int. 2023 Jun 22;178:108056. doi: 10.1016/j.envint.2023.108056. - AOP-helpFinder 2.0: Integration of an event-event searches module.
Jaylet T, Coustillet T, Jornod F, Margaritte-Jeannin P, Audouze K.
Environ Int. 2023 Jun 3; doi: 10.1016/j.envint.2023.108017. Epub ahead of print. - Combining the Classification and Pharmacophore Approaches to Understand Homogeneous Olfactory Perceptions at Peripheral Level: Focus on Two Aroma Mixtures.
Rugard M, Audouze K, Tromelin A.
Molecules. 2023 May 11;28(10):4028. doi: 10.3390/molecules28104028. - ReadEDTest: A tool to assess the readiness of in vitro test methods under development for identifying endocrine disruptors
Crouzet T, Grignard E, Brion F, Blanc EB, Podechard N, Langouet S, Alonso-Magdalena P, Hubert P, Kim MJ, Audouze K.
Environ Int. 2023 Apr;174:107910. doi: 10.1016/j.envint.2023.107910. Epub 2023 Mar 31. - Integrating -omics approaches into population-based studies of endocrine disrupting chemicals: A scoping review.
Maitre L, Jedynak P, Gallego M, Ciaran L, Audouze K, Casas M, Vrijheid M.
Environ Res. 2023 Jul 1;228:115788. doi: 10.1016/j.envres.2023.115788. Epub 2023 Mar 31. - Gene-environment interactions in the associations of PFAS exposure with insulin sensitivity and beta-cell function in a Faroese cohort followed from birth to adulthood.
Valvi D, Christiani DC, Coull B, Højlund K, Nielsen F, Audouze K, Su L, Weihe P, Grandjean P.
Environ Res. 2023 Jun 1;226:115600. doi: 10.1016/j.envres.2023.115600. Epub 2023 Mar 1. - Childhood exposure to non-persistent endocrine disrupting chemicals and multi-omic profiles: A panel study.
Fabbri L, Garlantézec R, Audouze K, Bustamante M, Carracedo Á, Chatzi L, Ramón González J, Gražulevičienė R, Keun H, Lau CE, Sabidó E, Siskos AP, Slama R, Thomsen C, Wright J, Lun Yuan W, Casas M, Vrijheid M, Maitre L.
Environ Int. 2023 Mar;173:107856. doi: 10.1016/j.envint.2023.107856. Epub 2023 Feb 26. - Cigarette smoke and tumor microenvironment copromote aggressiveness of human breast cancer cells.
Benoit L, Tomkiewicz C, Delit M, Khider H, Audouze K , Kowandy F, Bortoli S, Barouki R, Coumoul K, Koual M.
Toxicol Sci. 2023 Mar 20;192(1):30-42. doi: 10.1093/toxsci/kfad013. - Application of AOPs to assist regulatory assessment of chemical risks – Case studies, needs and recommendations.
Bajard L, Adamovsky O, Audouze K , Baken K, Barouki R , Beltman JB, Beronius A, Bonefeld-Jørgensen EC, Cano-Sancho G, de Baat ML, Di Tillio F, Fernández MF, FitzGerald RE, Gundacker C, Hernández AF, Hilscherova K, Karakitsios S, Kuchovska E, Long M, Luijten M, Majid S, Marx-Stoelting P, Mustieles V, Negi CK, Sarigiannis D, Scholtz S, Sovadinova I, Stierum R, Tanabe S, Tollefsen KE, van den Brand AD, Vogs C, Wielsøe M, Wittwehr C, Blaha L.
Environ Res. 2023 Jan 15;217:114650. doi: 10.1016/j.envres.2022.114650. Epub 2022 Oct 27.
2022
Peer-reviewed journal articles
- Partitioning of Persistent Organic Pollutants between Adipose Tissue and Serum in Human Studies.
Moriceau MA, Cano-Sancho G, Kim M, Coumoul X, , Emond C, Arrebola JP, Antignac JP, Audouze K, , Rousselle C.
Toxics. 2022 Dec 31;11(1):41. doi: 10.3390/toxics11010041. - Reduced Birth Weight and Exposure to Per- and Polyfluoroalkyl Substances: A Review of Possible Underlying Mechanisms Using the AOP-HelpFinder.
Gundacker C,Audouze K ,Widhalm R, Granitzer S, Forsthuber M, Jornod F, Wielsøe M, Long M, Halldórsson TI, Uhl M, Bonefeld-Jørgensen EC.
Toxics. 2022 Nov 12;10(11):684. doi: 10.3390/toxics10110684 - Application of artificial intelligence to decode the relationships between smell, olfactory receptors and small molecules
Achebouche R, Tromelin A, Audouze K , Taboureau O.
Sci Rep. 2022 Nov 5;12(1):18817. doi: 10.1038/s41598-022-23176-y. - Application of AOPs to assist regulatory assessment of chemical risks – Case studies, needs and recommendations.
Bajard L, Adamovsky O, Audouze K , Baken K, Barouki R , Beltman JB, Beronius A, Bonefeld-Jørgensen EC, Cano-Sancho G, de Baat ML, Di Tillio F, Fernández MF, FitzGerald RE, Gundacker C, Hernández AF, Hilscherova K, Karakitsios S, Kuchovska E, Long M, Luijten M, Majid S, Marx-Stoelting P, Mustieles V, Negi CK, Sarigiannis D, Scholtz S, Sovadinova I, Stierum R, Tanabe S, Tollefsen KE, van den Brand AD, Vogs C, Wielsøe M, Wittwehr C, Blaha L.
Environ Res. 2022 Oct 26:114650. doi: 10.1016/j.envres.2022.114650. Epub ahead of print. - Radiation Adverse Outcome Pathways (AOPs) are on the Horizon: Advancing Radiation Protection through an International Horizon-Style Exercisewe
Burtt JJ, Leblanc J, Randhawa K, Ivanova A, Rudd MA, Wilkins R, Azzam EI, Hecker M, Horemans N, Vandenhove H, Adam-Guillermin C, Armant O, Klokov D, Audouze K, Kaiser JC, Moertl S, Lumniczky K, Tanaka IB 3rd, Yamada Y, Hamada N, Al-Nabulsi I, Preston J, Bouffler S, Applegate K, Cool D, Beaton D, Tollefsen KE, Garnier-Laplace J, Laurier D, Chauhan V.
Int J Radiat Biol. 2022 Sep 6:1-34. doi: 10.1080/09553002.2022.2121439.. - Developing human biomonitoring as a 21st century toolbox within the European exposure science strategy 2020-2030
Zare Jeddi M, Hopf NB, Louro H, Viegas S, Galea KS, Pasanen-Kase R, Santonen T, Mustieles V, Fernandez MF, Verhagen H, Bopp SK, Antignac JP, David A, Mol H, Barouki R, Audouze K, Duca RC, Fantke P, Scheepers P, Ghosh M, Van Nieuwenhuyse A, Lobo Vicente J, Trier X, Rambaud L, Fillol C, Denys S, Conrad A, Kolossa-Gehring M, Paini A, Arnot J, Schulze F, Jones K, Sepai O, Ali I, Brennan L, Benfenati E, Cubadda F, Mantovani A, Bartonova A, Connolly A, Slobodnik J, Bruinen de Bruin Y, van Klaveren J, Palmen N, Dirven H, Husøy T, Thomsen C, Virgolino A, Röösli M, Gant T, von Goetz N, Bessems J.
Int. 2022 Aug 28;168:107476. doi: 10.1016/j.envint.2022.107476.. - Development of an adverse outcome pathway for radiation-induced microcephaly via expert consultation and machine learning
Jaylet T, Quintens R, Benotmane MA, Luukkonen J, Tanaka IB 3rd, Ibanez C, Durand C, Sachana M, Azimzadeh O, Adam-Guillermin C, Tollefsen KE, Laurent O, Audouze K, Armant O.
Int J Radiat Biol. 2022 Aug 18:1-11. doi: 10.1080/09553002.2022.2110312. - Combinatorial pathway disruption is a powerful approach to delineate metabolic impacts of endocrine disruptors.
Bernal K, Touma C, Erradhouani C, Boronat-Belda T, Gaillard L, Al Kassir S, Le Mentec H, Martin-Chouly C, Podechard N, Lagadic-Gossmann D, Langouet S, Brion F, Knoll-Gellida A, Babin PJ, Sovadinova I, Babica P, Andreau K, Barouki R, Vondracek J, Alonso-Magdalena P, Kim MJ, Coumoul X.
FEBS Lett. 2022 Aug 11. doi: 10.1002/1873-3468.14465. - Characterization of Potential Adverse Outcome Pathways Related to Metabolic Outcomes and Exposure to Per- and Polyfluoroalkyl Substances Using Artificial Intelligence.
Kaiser AM, Zare Jeddi M, Uhl M, Jornod F, Fernandez MF, Audouze K.
Toxics. 2022 Aug 4;10(8):449. doi: 10.3390/toxics10080449. - Adverse outcome pathway from activation of the AhR to breast cancer-related death
Benoit L, Jornod F, Zgheib E, Tomkiewicz C, Koual M, Coustillet T, Barouki R, Audouze K, Vinken M, Coumoul X.
Environ Int. 2022 Jul;165:107323. doi: 10.1016/j.envint.2022.107323 - Obesity III: Obesogen assays: Limitations, strengths, and new directions.
Kassotis CD, Vom Saal FS, Babin PJ, Lagadic-Gossmann D, Le Mentec H, Blumberg B, Mohajer N, Legrand A, Munic Kos V, Martin-Chouly C, Podechard N, Langouët S, Touma C, Barouki R, Kim MJ, Audouze K, Choudhury M, Shree N, Bansal A, Howard S, Heindel JJ.
Pharmacol. 2022 May;199:115014. doi: 10.1016/j.bcp.2022.115014 - Obesity II: Establishing causal links between chemical exposures and obesity.
Heindel JJ, Howard S, Agay-Shay K, Arrebola JP, Audouze K, Babin PJ, Barouki R, Bansal A, Blanc E, Cave MC, Chatterjee S, Chevalier N, Choudhury M, Collier D, Connolly L, Coumoul X, Garruti G, Gilbertson M, Hoepner LA, Holloway AC, Howell G 3rd, Kassotis CD, Kay MK, Kim MJ, Lagadic-Gossmann D, Langouet S, Legrand A, Li Z, Le Mentec H, Lind L, Monica Lind P, Lustig RH, Martin-Chouly C, Munic Kos V, Podechard N, Roepke TA, Sargis RM, Starling A, Tomlinson CR, Touma C, Vondracek J, Vom Saal F, Blumberg B.
Biochem Pharmacol. 2022 May;199:115015. doi: 10.1016/j.bcp.2022.115015 - Obesity I: Overview and molecular and biochemical mechanisms.
Lustig RH, Collier D, Kassotis C, Roepke TA, Kim MJ, Blanc E, Barouki R, Bansal A, Cave MC, Chatterjee S, Choudhury M, Gilbertson M, Lagadic-Gossmann D, Howard S, Lind L, Tomlinson CR, Vondracek J, Heindel JJ.
Biochem Pharmacol. 2022 May;199:115012. doi: 10.1016/j.bcp.2022.115012 - TCDD aggravates the formation of the atherosclerotic plaque in ApoE KO mice with a sexual dimorphic pattern.
Bey L, Coumoul X, Kim MJ
Biochimie. 2022 Apr;195:54-58. doi: 10.1016/j.biochi.2022.01.012 - Merging the exposome into an integrated framework for “omics” sciences.
Price EJ, Vitale CM, Miller GW, David A, Barouki R, Audouze K, Walker DI, Antignac JP, Coumoul X, Bessonneau V, Klánová J
iScience. 2022 Feb 24;25(3):103976. doi: 10.1016/j.isci.2022.103976 - Perturbateurs endocriniens : un risque débattu
Hill C, Barouki R, Audouze K, Coumoul X,
La revue du praticien , 2022 Jan 21; 72(1);13-6 - Emerging Bioinformatics Methods and Resources in Drug Toxicology
Taboureau O, Audouze K.
Methods Mol Biol. 2022;2425:133-146. doi: 10.1007/978-1-0716-1960-5_6
2021
- Mitochondrial Dysfunction as a Hallmark of Environmental Injury.
Duarte-Hospital C, Tête A, Brial F, Benoit L, Koual M, Tomkiewicz C, Kim MJ, Blanc EB, Coumoul X, Bortoli S.
Cells. 2021 Dec 30;11(1):110. doi: 10.3390/cells11010110 - Capturing a Comprehensive Picture of Biological Events From Adverse Outcome Pathways in the Drug Exposome.
Wu Q, Bagdad Y, Taboureau O, Audouze K.
Front Public Health. 2021; Dec 17 9:763962. doi:10.3389/fpubh.2021.763962 - The exposome and toxicology: a win-win collaboration.
Barouki R, Audouze K, Becker C, Blaha L,Coumoul X,Karakitsios S, Klanova J, Miller GW, Price EJ, Sarigiannis D.
Toxicol Sci. 2021 Dec 8:kfab149. doi: 10.1093/toxsci/kfab149. Online ahead of print. - Development of a chemogenomics library for phenotypic screening.
Dafniet B, Cerisier N, Boezio B, Clary A, Ducrot P, Dorval T, Gohier A, Brown D, Audouze K,Taboureau O.
J Cheminform. 2021 Nov 24;13(1):91. doi: 10.1186/s13321-021-00569-1 - AOP-helpFinder webserver: a tool for comprehensive analysis of the literature to support adverse outcome pathways development
Jornod F, Jaylet T, Blaha L, Sarigiannis D, Tamisier L, Audouze K.
Bioinformatics. 2021 Oct 30;38(4):1173–5. doi: 10.1093/bioinformatics/btab750. - Que sait on de l’action des perturbateurs endocriniens sur le métabolisme et l’obésité?
Kim Min J, Blanc E. Audouze K.
La revue du praticien, 2021 Sept. 27 ;71(7):723)-6 - Perturbateurs endocriniens: de quoi parle t’on, et quels nouveaux mécanismes de toxicité mettent ils en jeu?
Barouki R, Audouze K, Coumoul X.
La revue du praticien, 2021 Sept. 27 ;71(7):723)-6 - Associations between Exposure to Organochlorine Chemicals and Endometriosis: A Systematic Review of Experimental Studies and Integration of Epidemiological Evidence
Matta K, Koual M, Ploteau S, Coumoul X, Audouze K, Le Bizec B, Antignac JP, Cano-Sancho G
Environ Health Perspect. 2021 Jul;129(7):76003. doi: 10.1289/EHP8421 - Identification of non-validated endocrine disrupting chemical characterization methods by screening of the literature using artificial intelligence and by database exploration.
Zgheib E, Kim MJ, Jornod F, Bernal K, Tomkiewicz C, Bortoli S, Coumoul X, Barouki R, De Jesus K, Grignard E, Hubert P, Katsanou ES, Busquet F, Audouze K.
Environ Int. 2021 Apr 23;154:106574. doi: 10.1016/j.envint.2021.106574. Online ahead of print. - Smell compounds classification using UMAP to increase knowledge of odors and molecular structures linkages.
Rugard M, Jaylet T, Taboureau O, Tromelin A, Audouze K.
PLoS One. 2021 May 28;16(5):e0252486. doi: 10.1371/journal.pone.0252486. eCollection 2021. - Endocrine Disrupting Chemicals: Current Understanding, New Testing Strategies and Future Research Needs.
Street ME, Audouze K, Legler J, Sone H, Palanza P.
Int J Mol Sci. 2021 Jan 19;22(2):933. doi: 10.3390/ijms22020933. - Development of an adverse drug event network to predict drug toxicity
Q Wu, O Taboureau, K Audouze
Current Research in Toxicology 1, 48-55
2020
2020
- The COVID-19 pandemic and global environmental change: Emerging research needs.
Barouki R, Kogevinas M, Audouze K, Belesova K, Bergman A, Birnbaum L, Boekhold S, Denys S, Desseille C, Drakvik E, Frumkin H, Garric J, Destoumieux-Garzon D, Haines A, Huss A, Jensen G, Karakitsios S, Klanova J, Koskela IM, Laden F, Marano F, Franziska Matthies-Wiesler E, Morris G, Nowacki J, Paloniemi R, Pearce N, Peters A, Rekola A, Sarigiannis D, Šebková K, Slama R, Staatsen B, Tonne C, Vermeulen R, Vineis P; HERA-COVID-19 working group.
Environ Int. 2021 Jan;146:106272. doi: 10.1016/j.envint.2020.106272. Epub 2020 Nov 19. - Endocrine disrupting chemicals and COVID-19 relationships: A computational systems biology approach.
Wu Q, Coumoul X, Grandjean P, Barouki R, Audouze K.
Environ Int. 2020 Oct 30:106232. doi: 10.1016/j.envint.2020.106232. Online ahead of print. - Drug-target-ADR Network and Possible Implications of Structural Variants in Adverse Events.
Dafniet B, Cerisier N, Audouze K, Taboureau O
Mol Inform. 2020 Dec;39(12):e2000116. doi: 10.1002/minf.202000116. Epub 2020 Aug 28. - AOP4EUpest: mapping of pesticides in adverse outcome pathways using a text mining tool.
Jornod F, Rugard M, Tamisier L, Coumoul X, Andersen HR, Barouki R, Audouze K.
Bioinformatics. 2020 Aug 1;36(15):4379-4381. doi: 10.1093/bioinformatics/btaa545 - Integrative systems toxicology to predict human biological systems affected by exposure to environmental chemicals.
Taboureau O, El M’Selmi W, Audouze K.
Toxicol Appl Pharmacol. 2020 Oct 15;405:115210. doi: 10.1016/j.taap.2020.115210. Epub 2020 Aug 27 - Exploring the Characteristics of an Aroma-Blending Mixture by Investigating the Network of Shared Odors and the Molecular Features of Their Related Odorants.
Tromelin A, Koensgen F, Audouze K, Guichard E, Thomas-Danguin T.
Molecules. 2020 Jul 2;25(13):3032. doi: 10.3390/molecules25133032. - Endocrine disrupting chemicals and COVID-19 relationships: a computational systems biology approach.
Wu Q, Coumoul X, Grandjean P, Barouki R, Audouze K.
medRxiv. 2020 Jul 15:2020.07.10.20150714. doi: 10.1101/2020.07.10.20150714. Preprint. - Integrative Strategy of Testing Systems for Identification of Endocrine Disruptors Inducing Metabolic Disorders-An Introduction to the OBERON Project.
Audouze K, Sarigiannis D, Alonso-Magdalena P, Brochot C, Casas M, Vrijheid M, Babin PJ, Karakitsios S, Coumoul X, Barouki R.
Int J Mol Sci. 2020 Apr 23;21(8):2988. doi: 10.3390/ijms21082988. - Computational systems biology as an animal-free approach to characterize toxicological effects of persistent organic pollutants.
Wu Q, Achebouche R, Audouze K.
ALTEX. 2020;37(2):287-299. doi: 10.14573/altex.1910161. Epub 2020 Jan 21. - Deciphering Adverse Outcome Pathway Network Linked to Bisphenol F Using Text Mining and Systems Toxicology Approaches.
Rugard M, Coumoul X, Carvaillo JC, Barouki R, Audouze K.
Toxicol Sci. 2020 Jan 1;173(1):32-40. doi: 10.1093/toxsci/kfz214.
2019
2019
- Integrative Strategy of Testing Systems for Identification of Endocrine Disruptors Inducing Metabolic Disorders.
K Audouze, M Vrijheid, C Brochot, PJ Babin, Dimosthenis Sarigiannis, Spyridon Karakitsios, M Casas, R Barouki, P Alonso-Magdalena, X Coumoul
International Journal of Molecular Sciences - sAOP: linking chemical stressors to adverse outcomes pathway networks.
Aguayo-Orozco A, Audouze K, Siggaard T, Barouki R, Brunak S, Taboureau O.
Bioinformatics. 2019 Dec 15;35(24):5391-5392. doi: 10.1093/bioinformatics/btz570. - Conflicting associations between dietary patterns and changes of anthropometric traits across subgroups of middle-aged women and men.
Jiang L, Audouze K, Romero Herrera JA, Ängquist LH, Kjærulff SK, Izarzugaza JMG, Tjønneland A, Halkjær J, Overvad K, Sørensen TIA, Brunak S.
Clin Nutr. 2020 Jan;39(1):265-275. doi: 10.1016/j.clnu.2019.02.003. Epub 2019 Feb 14. - Linking Bisphenol S to Adverse Outcome Pathways Using a Combined Text Mining and Systems Biology Approach.
Carvaillo JC, Barouki R, Coumoul X, Audouze K.
Environ Health Perspect. 2019 Apr;127(4):47005. doi: 10.1289/EHP4200. - Multivariate statistical analysis of a large odorants database aimed at revealing similarities and links between odorants and odors
A Tromelin, C Chabanet, K Audouze, F Koensgen, E Guichard
Flavour and Fragrance Journal 33 (1), 106-126 - Epigenetics as a mechanism linking developmental exposures to long-term toxicity
R Barouki, E Melén, Z Herceg, J Beckers, J Chen, M Karagas, A Puga, Y Xia, L Chadwick, W Yan, K Audouze, R Slama, J Heindel, P Grandjean, T Kawamoto, K Nohara
Environment international 114, 77-86
2018
2018
- Integration of the human exposome with the human genome to advance medicine.
Barouki R, Audouze K, Coumoul X, Demenais F, Gauguier D.
Biochimie. 2018 Sep;152:155-158. doi: 10.1016/j.biochi.2018.06.023. Epub 2018 Jun 28. - Epigenetics as a mechanism linking developmental exposures to long-term toxicity.
Barouki R, Melén E, Herceg Z, Beckers J, Chen J, Karagas M, Puga A, Xia Y, Chadwick L, Yan W, Audouze K, Slama R, Heindel J, Grandjean P, Kawamoto T, Nohara K
Environ Int. 2018 May;114:77-86. doi: 10.1016/j.envint.2018.02.014. Epub 2018 Feb 27. - A systems biology approach to predictive developmental neurotoxicity of a larvicide used in the prevention of Zika virus transmission.
Audouze K, Taboureau O, Grandjean P.
Toxicol Appl Pharmacol. 2018 Sep 1;354:56-63. doi: 10.1016/j.taap.2018.02.014. Epub 2018 Feb 21.
2017
2017
- Network-based Approaches in Pharmacology.
Boezio B, Audouze K, Ducrot P, Taboureau O.
Mol Inform. 2017 Oct;36(10). doi: 10.1002/minf.201700048. Epub 2017 Jul 10.
2016
2016
- Human Environmental Disease Network: A computational model to assess toxicology of contaminants.
Taboureau O,Audouze K
ALTEX. 2017;34(2):289-300. doi: 10.14573/altex.1607201. Epub 2016 Oct 21.
Communication
2023
2020
2019
Conference presentations (oral and posters)
The SysTox group is present at various international events (SETAC, SOT, EuroTox, Estiv…)
And some more …
2021
2020
- Fête de la science: Qu’est ce que la pandémie Covid-19 nous apprend de notre relation santé-environnement?
- Tour des sciences: Les AOPs pour tous!
- Journées des patients Inserm
- Le lycée au labo: la bioinformatique
- Société Francophone de Santé et Environnement/ M. Rugard
2019
Peer-reviewed journal articles
- A journey into the regulatory secrets of the de novo purine nucleotide biosynthesis [Review]
Frontiers in Pharmacology, 15. https://doi.org/10.3389/fphar.2024.1329011
- Synthesis, evaluation and mechanistic insights of novel IMPDH inhibitors targeting ESKAPEE bacteria
European Journal of Medicinal Chemistry, 280, 116920. https://doi.org/10.1016/j.ejmech.2024.116920
- An equine iPSC-based phenotypic screening platform identifies pro- and anti-viral molecules against West Nile virus
Veterinary Research, 55(1), 32. https://doi.org/10.1186/s13567-024-01290-1
2023
Peer-reviewed journal articles
- SigH stress response mediates killing of Mycobacterium tuberculosis by activating nitronaphthofuran prodrugs via induction of Mrx2 expression
Nucleic Acids Res, 51(1), 144-165. https://doi.org/10.1093/nar/gkac1173
- Novel Antiviral Molecules against Ebola Virus Infection
International Journal of Molecular Sciences, 24(19), 14791. https://www.mdpi.com/1422-0067/24/19/14791
- Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMP dehydrogenases
Protein Sci, 32(8), e4703. https://doi.org/10.1002/pro.4703
- Interaction network among de novo purine nucleotide biosynthesis enzymes in Escherichia coli
Febs J, 290(12), 3165-3184. https://doi.org/10.1111/febs.16746
- Modulation of the functional interfaces between retroviral intasomes and the human nucleosome
mBio, 14(4), e0108323. https://doi.org/10.1128/mbio.01083-23
- Discovery of Bis-Imidazoline Derivatives as New CXCR4 Ligands
Molecules, 28(3), 1156. https://doi.org/10.3390/molecules28031156
2022
Peer-reviewed journal articles
- Steroid hormone catabolites activate the pyrin inflammasome through a non-canonical mechanism
Cell Rep, 41(2), 111472. https://doi.org/10.1016/j.celrep.2022.111472
- Structural basis for the allosteric inhibition of UMP kinase from Gram-positive bacteria, a promising antibacterial target
Febs J, 289(16), 4869-4887. https://doi.org/10.1111/febs.16393
2021
2021
- 2-((3,5-Dinitrobenzyl)thio)quinazolinones: Potent Antimycobacterial Agents Activated by Deazaflavin (F420)-Dependent Nitroreductase (Ddn)
J Med Chem, 64(1), 440-457. https://doi.org/10.1021/acs.jmedchem.0c01374
- SARS-CoV-2 Nsp3 unique domain SUD interacts with guanine quadruplexes and G4-ligands inhibit this interaction
Nucleic Acids Res, 49(13), 7695-7712. https://doi.org/10.1093/nar/gkab571
- Structure-aided optimization of non-nucleoside M. tuberculosis thymidylate kinase inhibitors
Eur J Med Chem, 225, 113784. https://doi.org/10.1016/j.ejmech.2021.113784
2020
2020
- A real-time cell-binding assay reveals dynamic features of STxB-Gb3 cointernalization and STxB-mediated cargo delivery into cancer cells
FEBS Lett, 594, 2406-2420. https://doi.org/10.1002/1873-3468.13847
- 1-(1-Arylethylpiperidin-4-yl)thymine Analogs as Antimycobacterial TMPK Inhibitors
Molecules, 25(12), 2805. https://doi.org/10.3390/molecules25122805
- Synthesis and structure activity relationships of cyanopyridone based anti-tuberculosis agents
Eur. J. Med. Chem., 201, 112450. https://doi.org/10.1016/j.ejmech.2020.112450
- Endeavors towards transformation of M. tuberculosis thymidylate kinase (MtbTMPK) inhibitors into potential antimycobacterial agents
Eur. J. Med. Chem., 206, 112659. https://doi.org/10.1016/j.ejmech.2020.112659
- Identification of antiviral compounds against equid herpesvirus-1 using real-time cell assay screening: efficacy of decitabine and valganciclovir alone or in combination
Antiviral Res, 104931. https://doi.org/10.1016/j.antiviral.2020.104931
- Replication of Equine arteritis virus is efficiently suppressed by purine and pyrimidine biosynthesis inhibitors
Scientific Reports, 10(1), 10100. https://doi.org/10.1038/s41598-020-66944-4
2019
2019
- First-in-class allosteric inhibitors of bacterial IMPDHs
Eur J Med Chem, 167, 124-132. https://doi.org/10.1016/j.ejmech.2019.01.064
- 1-(Piperidin-3-yl)thymine amides as inhibitors of M. tuberculosis thymidylate kinase
J. Enzyme Inhib. Med. Chem., 34(1), 1730-1739. https://doi.org/10.1080/14756366.2019.1662790
- Screening and evaluation of antiviral compounds against Equid alpha-herpesviruses using an impedance-based cellular assay
Virology, 526, 105-116. https://doi.org/10.1016/j.virol.2018.10.013
2018
2018
- Identification of novel leishmanicidal molecules by virtual and biochemical screenings targeting Leishmania eukaryotic initiation factor 4A
PLoS Negl Trop Dis, 12(1), e0006160. https://doi.org/10.1371/journal.pntd.0006160
- A Novel Polyaminocarboxylate Compound To Treat Murine Pulmonary Aspergillosis by Interfering with Zinc Metabolism
Antimicrob Agents Chemother, 62(6), e02510-02517. https://doi.org/10.1128/AAC.02510-17
- Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors
J Med Chem, 61(7), 2753-2775. https://doi.org/10.1021/acs.jmedchem.7b01570
- Synthesis of sulfamide analogues of deoxthymidine monophosphate as potential inhibitors of mycobacterial cell wall biosynthesis
Carbohydrate Research, 457, 32-40. https://doi.org/10.1016/j.carres.2018.01.001
2017
2017
- Nitazoxanide Analogs Require Nitroreduction for Antimicrobial Activity in Mycobacterium smegmatis
J. Med. Chem., 60(17), 7425-7433. https://doi.org/10.1021/acs.jmedchem.7b00726
- Inhibition of the inflammatory response to stress by targeting interaction between PKR and its cellular activator PACT
Scientific Reports, 7(1), 16129. https://doi.org/10.1038/s41598-017-16089-8
- Identification of a small molecule that primes the type I interferon response to cytosolic DNA
Scientific Reports, 7(1), 2561. https://doi.org/10.1038/s41598-017-02776-z
- Tetrahydro-2-furanyl-2,4(1H,3H)-pyrimidinedione derivatives as novel antibacterial compounds against Mycobacterium
Int. J. Mycobacteriol., 6(1), 61-69. https://doi.org/10.4103/2212-5531.201893
- Original Chemical Series of Pyrimidine Biosynthesis Inhibitors That Boost the Antiviral Interferon Response
Antimicrobial Agents and Chemotherapy, 61(10), e00383-00317. https://doi.org/10.1128/AAC.00383-17
2016
2016
- Anti-mycobacterial activity of thymine derivatives bearing boron clusters
Eur. J. Med. Chem., 121, 71-81. https://doi.org/10.1016/j.ejmech.2016.05.030
- Respiratory syncytial virus infection in macaques is not suppressed by intranasal sprays of pyrimidine biosynthesis inhibitors
Antiviral Research, 125, 58-62. https://doi.org/10.1016/j.antiviral.2015.11.006
- Administration of zinc chelators improves survival of mice infected with Aspergillus fumigatus both in monotherapy and in combination with caspofungin
Antimicrobial Agents and Chemotherapy, 60(10), 5631-5639. https://doi.org/10.1128/AAC.00324-16
- The Toxicity of a Novel Antifungal Compound Is Modulated by Endoplasmic Reticulum-Associated Protein Degradation Components
Antimicrobial Agents and Chemotherapy, 60(3), 1438-1449. https://doi.org/10.1128/AAC.02239-15
- Elaboration of a proprietary thymidylate kinase inhibitor motif towards anti-tuberculosis agents
Bioorg Med Chem, 24(21), 5172-5182. https://doi.org/10.1016/j.bmc.2016.08.041